Resources

Posters
20 May 2025
Small samples, big insights: Accelerating AAV stability studies with high-quality, low volume analytics
A. Stockinger, C. Zach, B. Hager, M. Weidler, M. Goja, T. Kloetzerer, R. Volland, S. Harbich, N. Spada, A. Schoberth, P. Reck, SM Schermann
Adeno-associated virus (AAV) products are at the forefront of gene therapy innovation; yet their inherent complexity poses significant challenges for characterization and regulatory compliance in research and development as well as commercial production settings. In response, we have developed an extensive portfolio of in-house analytical capabilities tailored to the needs of viral gene therapy products. To showcase these capabilities, we conducted a stability study that encompasses a comprehensive set of methods and quality parameters.
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Posters
15 May 2025
The Good, the Bad, Er the Chimeric: Using Nanopore Sequencing to De-Risk rAAV Genome Packaging
K BREUNIG, F DUNKER-SEIDLER, M HAUBNER, F SONNTAG M HOERER, RC FEINER
Poster #829
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Posters
15 May 2025
The Fab Four — validated GMP QC assays to more reliably assess DNA impurities for rAAV batch release
Felicia Thoennissen, Marina Magerl, Paul Zanotti, Sophie Beer, Renee Kober, Sonya M. Schermann, Sabine Geiger
Poster #1323
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Posters
15 May 2025
Gaining control of rAAV production: real-time monitoring with Raman Spectroscopy
B L CARNIO1, J WAGNER1, NI BOSCHER1, J BABIC1, D BITNEL1, T FISCHER1, S NDONWI1, H EL RADI2, L SAVARY2, C ZACH1, B HAGER1, S RITTER1, M GORA1, T KLOETZLER1, M WEIDLER1, A SCHOBERTH1, M LANGHAUSER1 M HOERER1, K HELLER1, A YOUSSEF1
Poster #1941
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Posters
15 May 2025
High yield & full-empty ratios achieved with a scalable GMP-ready AEX chromatography
E Tsiaousi, J Trommer, C Mantzoros, M Boscher, J Wagner, J Babic, B L Carnio, C Zach, S Ritter, M Gora, T Kloetzler, A Schoberth, A Youssef, M Langhauser
Poser #1457
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Posters
15 May 2025
Extraction-free ddPCR quantification of host-cell derived E1A impurities in rAAV samples
S Beer, P Zanotti, T Klötzler, F Thoennissen, S Geiger, S M Schermann, R Kober
#Poster 1842
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Posters
15 May 2025
ABL’s HIV p24 ELISA Kit: a Solution for Lentivirus Quantification in Industrial Processes
Shanshan Zhu, Wei Zou, Poorni Adikaram, Jian Wang, Madeline Kalisz, Vivek Shukla, Shayesteh Fathieh, Krishna Chauhan, Isabelle Pelletier, Tyler Frazier, Ran-Der Hwang, Leon Toussaint, Elena Gustchina, Peter Silvera, Brian Tyler and Timothy Fouts
Poster #1789
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White Papers
5 May 2025
Solving the AAV Scalability Challenge
Ahmed Youssef, Senior Manager of Upstream Process Development at Ascend • Melanie Plath, Application Specialist Bioreactor Technologies at Sartorius Stedim Biotech GmbH
See how our team worked with Sartorius to demonstrate consistent productivity, quality, and potency from 250 mL to 200 L scales.
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White Papers
5 May 2025
Considerations for AAV Analytical Comparability Studies for Products with Low Batch Numbers
Sonya M. Schermann, Philipp Beck, Markus Hoerer
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One pagers
2 May 2025
Gene Therapy Process Development Support to Optimize AAV Yield & Quality from Gene to GMP Production
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One pagers
2 May 2025
Gene Therapy Formulation
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One pagers
2 May 2025
Analytics-driven AAV Development & Manufacturing
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