Resources

White Papers
7 August 2025
In-Line Monitoring of CPPs and Capsid Titer in Upstream AAV Process with ProCellics™ Raman Analyzer
This application note explores the use of the ProCellics™ Raman Analyzer for in-line monitoring of critical process parameters (CPPs) during the growth and production phase as well as post-lysis capsid titer in the bioreactor of an AAV production process that utilizes Human Embryonic Kidney (HEK) cell culture and transient transfection.
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White Papers
7 August 2025
Optimizing AAV Serotype Filtration
Sirri Ndonwi, Beatriz L Carnio, Dila Bitnel, Jared Babic, Tatjana Fischer, Matthias Boscher, Johanna Wagner, Ahmed Youssef, Benjamin Graf, Andreas Pickl
In this application note we present data showcasing the clear filtration of different AAV serotypes using Sartoclear Dynamics® Lab in combination with the Sartolab® Multistation.
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Posters
20 May 2025
Small samples, big insights: Accelerating AAV stability studies with high-quality, low volume analytics
A. Stockinger, C. Zach, B. Hager, M. Weidler, M. Gora, T. Kloetzler, R. Volland, S. Harbich, N. Spada, A. Schoberth, P. Beck, SM Schermann
ASGCT 2025 Poster #981
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Posters
15 May 2025
The Good, the Bad, and the Chimeric: Using nanopore sequencing to de-risk rAAV genome packaging
K BREUNIG, F DUNKER-SEIDLER, M HAUBNER, F SONNTAG M HOERER, RC FEINER
ASGCT 2025 Poster #829
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Posters
15 May 2025
The Fab Four — validated GMP QC assays to more reliably assess DNA impurities for rAAV batch release
F. Thoennissen, M. Magerl, P. Zanotti, S. Beer, R. Kober, S. M. Schermann, S. Geiger
ASGCT 2025 Poster #1323
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Posters
15 May 2025
Gaining control of rAAV production: real-time monitoring with Raman Spectroscopy
B L CARNIO, J WAGNER, NI BOSCHER, J BABIC, D BITNEL, T FISCHER, S NDONWI, H EL RADI, L SAVARY, C ZACH, B HAGER, S RITTER, M GORA, T KLOETZLER, M WEIDLER, A SCHOBERTH, M LANGHAUSER, M HOERER, K HELLER, A YOUSSEF
ASGCT 2025 Poster #1941
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Posters
15 May 2025
High yield & full-empty ratios achieved with a scalable GMP-ready AEX chromatography
E Tsiaousi, J Trommer, C Mantzoros, M Boscher, J Wagner, J Babic, B L Carnio, C Zach, S Ritter, M Gora, T Kloetzler, A Schoberth, A Youssef, M Langhauser
ASGCT 2025 Poster #1457
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Posters
15 May 2025
Extraction-free ddPCR quantification of host-cell derived E1A impurities in rAAV samples
S Beer, P Zanotti, T Klötzler, F Thoennissen, S Geiger, S M Schermann, R Kober
ASGCT 2025 #Poster 1842
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Posters
15 May 2025
ABL’s HIV p24 ELISA Kit: a Solution for Lentivirus Quantification in Industrial Processes
S Zhu, W Zou, P Adikaram, J Wang, M Kalisz, V Shukla, S Fathieh, K Chauhan, I Pelletier, T Frazier, R Hwang, L Toussaint, E Gustchina, P Silvera, B Tyler and T Fouts
ASGCT 2025 Poster #1789
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White Papers
5 May 2025
Solving the AAV Scalability Challenge
Ahmed Youssef, Senior Manager of Upstream Process Development at Ascend • Melanie Plath, Application Specialist Bioreactor Technologies at Sartorius Stedim Biotech GmbH
See how our team worked with Sartorius to demonstrate consistent productivity, quality, and potency from 250 mL to 200 L scales.
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White Papers
5 May 2025
Considerations for AAV Analytical Comparability Studies for Products with Low Batch Numbers
S M Schermann, P Beck, M Hoerer
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One pagers
2 May 2025
Gene Therapy Process Development Support to Optimize AAV Yield & Quality from Gene to GMP Production
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